Publications

Type of Publication:
71 :

"Double-Diels-Alder Approach to Maoecrystal V.  Unexpected C-C Bond-Forming Fragmentations of the [2.2.2]-Bicyclic Core" Smith, B. R.; Njardarson, J. T. Org. Lett. 2017, 19, 5316.



70 :

"New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures" Chogii, I.; Das, P.; Fell, J. S.; Scott, K. A.; Crawford, M. N.; Houk, K. N.; Njardarson, J. T. J. Am. Chem. Soc. 2017, 139, 13141.



69 :

"Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products" Smith, D. T.; Vitaku, E.; Njardarson J. T. Org. Lett. 2017, 19, 3508



Type of Publication: Publication
68 :

"A Mild Meta-Selective C-H Alkylation of Catechol Mono-Ethers" Vitaku, E.; Njardarson, J. T. Eur. J. Org. Chem. 2016, 3679.



67 :

"Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio- and Aminophosphate Precursors" Das, P.; Njardarson, J. T. Eur. J. Org. Chem. 2016, 4249.



66 :

"Metal-Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization" Vitaku, E.; Smith, D. T. ; Njardarson, J. T. Angew. Chem. Int. Ed. 2016, 55, 2243.



65 :

"Asymmetric [3+2] Annulation Approach to 3-Pyrrolines:  Concise Total Syntheses of (-)-Supinidine, (-)-Isoretronecanol and (+)-Elacomine" Chogii, I.; Njardarson, J. T. Angew. Chem. Int. Ed. 201554, 13706.



64 :

“Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches” Das, P.; Njardarson, J. T. Org. Lett. 2015, 17, 4030.



63 :

"Synthetic Approaches and Total Syntheses of Vinigrol, a Unique Diterpenoid" Draghici, C.; Njardarson, J. T. Tetrahedron 201571, 3775.



62 :

"Ring Expansions of Oxiranes and Oxetanes" Smith, D. T.; Njardarson, J. T. Topics in Heterocyclic Chemistry 2015, 41, 281.

61 :

"Formation of Fused Aromatic Architectures via an Oxidative Dearomatization - Radical Cyclization Rearomatization Approach" Vitaku, E.; Njardarson, J. T. Tetrahedron Lett. 201556, 3550 (Special issue in honor of Professor H. H. Wasserman)



60 :

“The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol”, Draghici, C.; Njardarson, J. T. Strategies and Tactics in Organic Synthesis 11 (Book chapter) 2015accepted.

59 :

"Beyond C, H, O and N!  Analysis of the Elemental Composition of US FDA Approved Drug Architectures" Smith, B. R.; Eastman, C. M.; Njardarson, J. T. J. Med. Chem. 201457, 9764.



58 :

"Analysis of the Structural Diversity, Substitution Patterns and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals" Vitaku, E.; Smith, D. T.; Njardarson, J. T. J. Med. Chem201457, 10257.



57 :

"Mild Stereoselective Formation of Tri- and Tetrasubstituted Olefins by Regioselective Ring Opening of 1,1-Disubstituted Vinyl Oxiranes with Dialkyl Dithiophosphates" Guo, B.; Vitaku, E.; Njardarson, J. T. Tetrahedron Lett. 201455, 3232.



56 :

"A Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction" Smith, D. T.; Njardarson, J. T. Angew. Chem. Int. Ed. 201453, 4278.

55 :

"Evolution of an Oxidative Dearomatization Enabled Total Synthesis of Vinigrol" Yang, Q.; Draghici, C.; Njardarson, J. T.; Li, F.; Smith, B. R.; Das, P. Org. Biomol. Chem. 201412, 330.                                        (Selected as an OBC Hot article)



54 :

"Base Mediated Deprotection Strategies for Trifluoroethyl (TFE) Ethers, a New Alcohol Protecting Group" Yang, Q.; Njardarson, J. T. Tetrahedron Lett. 201354, 7080.



53 :

"Data-mining for Sulfur and Fluorine:  An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery" Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. J. Med. Chem. 201457, 2832.



52 :

“Z-Selective Ring Opening of Vinyl Oxetanes with Dialkyl Dithiophosphate Nucleophiles” Guo, B.; Njardarson, J. T. Chem. Commun. 201349, 10802.



51 :

“Ring Expansions of Vinyl- Oxiranes, Thiiranes and Aziridines: Synthetic Approaches, Challenges and Catalytic Success Stories” Ilardi, E. A.; Njardarson, J. T.  J. Org. Chem. 201378, 9533.



50 :

"An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents that Chronicle Our Medicinal History" Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. J. Chem. Ed. 201390, 1403.



49 :

"Total Synthesis of Vinigrol" Yang, Q.; Njardarson, J. T.; Draghici, C.; Li, F. Angew. Chem. Int. Ed. 201352, 8648.     (Featured April 7th 2014 By Professor Taber on Organic Chemistry Portal)          Vinigrol featured in the October 2013 issue of Synform



48 :

"Catalytic Ring Expansion Adventures" Njardarson, J. T. Synlett2013, 787 (Invited Account)



47 :

"Recent Advances in the Metal-Catalyzed Ring Expansions of Three- and Four-Membered Rings" Mack, D. J.; Njardarson, J. T. ACS Catal. 20133, 272.



46 :

"Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process" Mustard, T. J. L.; Mack, D. J.; Njardarson, J. T.; Cheong, Paul. H.-Y. J. Am. Chem. Soc. 2013135, 1471.



45 :

"Syntheses and Structural Confirmations of Members of a Heterocycle-Containing Family of Labdane Diterpenoids" Mack, D. J.; Njardarson, J. T. Angew. Chem. Int. Ed. 201352, 1543.



44 :

"New Mechanistic Insights into the Copper Catalyzed Ring Expansion of Vinyl Aziridines:  Evidence in Support of a Copper(I) Mediated Pathway" Mack, D. J.; Njardarson, J. T. Chem. Sci. 20123, 3321.



43 :

"Reactions at your fingertips" Njardarson, J. T. Nature Chem. 20124, 590.

42 :

"Distinct Biological Effects of Golgicide A Derivatives on Larval and Adult Mosquitos" Mack, D. J.; Isoe, J.; Miesfeld, R. L.; Njardarson, J. T. Bioorg. Med. Chem. Lett. 201222, 5177.



41 :

"Synthesis of Allylic and Homoallylic Alcohols from Unsaturated Cyclic Ethers Using a Mild and Selective C-O Reduction Approach" Mack, D. J.; Guo, B.; Njardarson J. T. Chem. Commun. 201248, 7844.



40 :

"Catalytic Ring Expansion of VInyl Oxetanes:  Asymmetric Synthesis of Dihydropyrans Using Chiral Counterion Catalysis" Guo, B.; Schwarzwalder, G.; Njardarson, J. T. Angew. Chem. Int. Ed201251, 5675.



39 :

"Chemistry By Design - A Web Based Educational Flashcard for Exploring Synthetic Organic Chemistry" Draghici, C.; Njardarson, J. T. J. Chem. Ed. 201289, 1080.



38 :

"Pharmaceutical Structure Montages as Catalysts for Design and Discovery" Njardarson, J. T. Future Med. Chem20124, 951.

37 :

"Efficient Synthesis of Thiopyrans Using Sulfur-Enabled Anionic Cascade" Li, F.; Calabrese, D.; Brichacek, M.; Lin, I.; Njardarson, J. T. Angew. Chem. Int. Ed201251, 1938.



36 :

"Intermolecular Oxonium Ylide Mediated Synthesis of Medium-Sized Ocacycles" Mack, D. J.; Batory, L. A.; Njardarson, J. T. Org. Lett. 201214, 378.



35 :

"Emergence of Potent Inhibitors of Metastasis in Lung Cancer vis Syntheses Based on Migrastatin" Lecomte, N.; Njardarson, J. T.; Nagorny, P.; Yang, G.; Downey, R.; Ouerfelli, O.; Moore, M. A. S.; Danishefsky, S. J. Proc. Natl. Acad. Sci. U. S. A. 2011108, 15074.

34 :

Synthetic Efforts Toward [3.3.1] Bridged Bicyclic Phloroglucinol Natural Products” Njardarson, J. T. Tetrahedron 2011, 67, 7631 (Invited Report).



33 :

“Stereospecific Ring Expansion of Chiral Vinyl Aziridines” Brichacek, M.; Navarro Villalobos, M.; Plichta, A.; Njardarson J. T. Org. Lett. 201113, 1110.



32 :

“An Efficient Oxidative Dearomatization-Radical Cyclization Approach to Symmetrically Substituted Bicyclic Guttiferone Natural Products” McGrath, N. A.; Binner, J. R.; Markopoulos, G.; Brichacek, M.; Njardarson J. T. Chem. Commun. 201147, 209.



31 :

“The Strategic Marriage of Method and Motif. Total Synthesis of Varitriol” Brichacek, M.; Batory, L. A.; McGrath, N. A.; Njardarson J. T. Tetrahedron 2010, 66, 4832.



30 :

“A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives” McGrath, N. A.; Brichacek, M.; Njardarson J. T. J. Chem. Ed. 2010, 87, 1348.



29 :

“A Stereoselective Ring Expansion of Vinyl Oxiranes. Mechanistic Insights and Natural Product Total Synthesis” Brichacek, M.; Batory, L. A.; Njardarson, J. T. Angew. Chem. Int. Ed. 2010, 49, 1648.



28 :

“A Concise Ring Expansion Route to the Compact Core of Platensimycin” McGrath, N. A.; Bartlett, E. S.; Sittihan, S.; Njardarson, J. T. Angew. Chem., Int. Ed. 2009, 48, 8543.



27 :

“Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton” Morton, J. G. M.; Dragichi, C.; Kwon, L. D.; Njardarson, J. T. Org. Lett. 2009, 11, 4492.



26 :

“Creative Approaches Towards the Synthesis of 2,5-Dihydro- Furans, Thiophenes and Pyrroles. One Method Does Not Fit All!” Brichacek, M.; Njardarson, J. T. Org. Biomol. 2009, 7, 1761.



25 :

“Efforts Towards the Total Synthesis of Vinigrol” Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. Synlett 2009, 23.



24 :

“An Adler-Becker Oxidation Approach to Vinigrol” Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. Tetrahedron Lett. 2009, 50, 1684.



23 :

“An Efficient Substrate Controlled Synthesis of Hypoestoxide, a Member of a Unique Family of Diterpenoid Natural Products with an Inside-Out [9.3.1]Bicyclic Core” McGrath, N.; Lee, C. A.; Araki, H.; Brichacek, M.; Njardarson, J. T. Angew. Chem. Int. Ed. 2008, 47, 9450.



22 :

“Lewis Acid Catalyzed [1,3]-Sigmatropic Rearrangement of Vinyl Aziridines” Brichacek, M.; Njardarson, J. T.; Lee-D.-L. Org. Lett. 2008, 10, 5023.



21 :

“PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice” McDewitt, M. R.; Chattopadhyay, D.; Jaggi, J. S.; Finn, R. D.; Zanzonico, P. B.; Villa, C.; Rey, D.; Mendenhall, J.; Batt, C. A.; Njardarson, J. T.; Scheinberg, D. A. PLoS One 2007, 2.

20 :

“Tumor Targeting with Antibody-Functionalized Radiolabled Carbon Nanotubes” McDewitt, M. R.; Chattopadhyay, D.; Kappel, B. J.; Jaggi, J. S.; Schiffman, S. R.; Antczak, C.; Njardarson, J. T.; Brentjens, R.; Scheinberg, D. A. J. Nuc. Med. 2007, 48, 1180.

19 :

“Highly Selective Copper-Catalyzed Ring Expansion of Vinyl Thiiranes: Application to Synthesis of Biotin and the Heterocyclic Core of Plavix®” Rogers, E.; Araki, H.; Batory, L. A.; McInnis, C. E.; Njardarson, J. T. J. Am. Chem. Soc2007, 129, 2768.



18 :

“Copper Catalyzed Rearrangement of Vinyl Oxiranes” Batory, L. A.; McInnis, C. E.; Njardarson, J. T. J. Am. Chem. Soc. 2006, 128, 16054.



Type of Publication: graduate and post-doctoral publications
17 :

“Confirmation of the Structure of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims”Nagorny, P.; Krauss, I.; Njardarson, J. T.; Perez, L.; Gaul, G.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. Tetrahedron Lett. 2010, 51, 3873.

16 :

“Synthetic Analogues of Migrastatin That Inhibit Mammary Tumor Metastasis in Mice” Shan, D.; Chen, L.; Njardarson, J. T.; Gaul, C.; Ma, X.; Danishefsky, S. J.; Huang, X.-Y. Proc. Natl. Acad. Sc.i U. S. A. 2005, 102, 3772.

15 :

“The Migrastatin Family: Discovery of Promising Tumor Cell Migration Inhibitors by Chemical Synthesis” Gaul, C.; Njardarson, J. T.; Shan, D.; Dorn, D. C.; Wu, K.-D.; Tong, W. P.; Huang, X.-Y.; Moore, M. A.; Danishefsky, S. J. J. Am. Chem. Soc. 2004, 126, 11326.

14 :

“Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin” Njardarson, J. T.’ Gaul, C.; Shan, D.; Huang, X.-Y.; Danishefsky, S. J. J. Am. Chem. Soc. 2004, 126, 1038.

13 :

“Application of Phenolic Oxidation Chemistry in Synthesis: Preparation of the BCE Ring System of Ryanodine” Wood, J. L.; Graeber, J. K.; Njardarson, J. T. Tetrahedron 2003, 59, 8855.

12 :

“Radicicol and the Epothilones: Total Synthesis of Novel Anti Cancer Agents Using Ring Closing Metathesis” Njardarson, J. T.; Garbaccio, R. M.; Danishefsky, S. J., in “Handbook of Metathesis”, Ed. Grubbs, Robert H.; Wiley, New York, 2003, Chapter 2.9, Appendix 3, p353.

11 :

“Innovation and Art in Organic Chemistry: Synthetic Efforts Toward the Phomoidrides” Spiegel, D. A.; Njardarson, J. T.; McDonald, I.; Wood, J. L. Chem. Rev. 2003, 103, 2691.

10 :

“The Total Synthesis of (+)-Migrastatin” Gaul, C.; Njardarson, J. T.; Danishefsky, S. J. J. Am. Chem. Soc. 2003, 125, 6042.

09 :

“Application of Hitherto Unexplored Macrocyclization Strategies in the Epothilone Series: Novel Epothilone Analogs by Total Synthesis” Njardarson, J. T.; Biswas, K.; Danishefsky, S. J. Chem Commun2002, 2759.

08 :

“Total Syntheses of [17]- and [18]Dehydrodesoxyepothilones B via a Concise Ring-Closing Metathesis-Based Strategy: Correlation of Ring Size with Biological Activity in the Epothilones Series” Rivkin, A.; Njardarson, J. T.; Biswas, K.; Chou, T-C.; Danishefsky, S. J. J. Org. Chem. 2002, 67, 7737.

07 :

“Highly Concise Routes to Epothilones: The Total Synthesis and Evaluation of Epothilone 490” Biswas, K.; Lin, H.; Njardarson, J. T.; Chappell, M. D.; Chou, T.-C.; Guan, Y.; Tong, W. P.; He, L.; Horwitz, S. B.; Danishefsky, S. J. J. Am. Chem. Soc. 2002, 124, 9825.

06 :

“CP-263,114 Synthetic Studies. Construction of an Isotwistane Ring System via Rhodium Carbenoid C-H Insertion” Spiegel, D. A.; Njardarson, J. T.; Wood, J. L. Tetrahedron 2002, 58, 6545.

05 :

“Reactive Dienes: Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl)-propionic Acids” Drutu, I.; Njardarson, J. T.; Wood, J. L. Org. Lett. 2002, 4, 493.

04 :

“An Expeditious Approach Towards the Total Synthesis of CP-263,114” Njardarson, J. T.; MacDonald, I.; Spiegel, D. A.; Inoue, M.; Wood, J. L. Org. Lett. 2001, 3, 2435.

03 :

“Evolution of a Synthetic Approach to CP-263,114” Njardarson, J. T.; Wood, J. L. Org. Lett. 2001, 3, 2431.

02 :

e Synthetic Route to Pure Isomers of the Antifungal Agents (E)- and (Z)-1,2-Diaryl-3-(1-imidazolyl)-1-propenes” Geirsson, J. K. F.; Gudmundsson, B. O.; Johannesdottir, J. F.; Njardarson, J. T.; Skulason, V. Acta Chem. Scand. 1995, 49, 423.

01 :

“A Facile Synthesis of α-Phosphono Esters through Methoxycarbonylation of α-Phosphono Carbanions” Geirsson, J. K. F.; Njardarson, J. T. Tetrahedron Lett 1994, 35, 9071.

Type of Publication: Independent Patents
06 :

“Single Wall Carbon Nanotube Constructs For Targeting Tumors” Scheinberg, D.; McDewitt, M.; Antczak, C.; Chattopahyay, D.; May, R.; Njardarson, J.; Phillips M. R.; PCT Int. Appl., (2007), WO 2007016466.

05 :

“Process For the Preparation of 2,5-Dihydrofuran Derivatives” Njardarson, J. T.; Batory, L. A.; Bricachek, M.; Bauer, R. A.; Rogers, E. PCT Int. Appl., (2007), WO 2007108999.

Type of Publication: Patents From Post-Doctoral Work
04 :

 “Preparation of Migrastatin and its Analogs for use in Pharmaceutical Compositions for the Treatment of Cancer” Danishefsky, S. J.; Gaul, C.; Njardarson, J. T., Moore, M. A. S.; Wu, K.; Dorn, D. C.; Mandal, M.; PCT Int. Appl., (2006), WO 2006001967.

03 :

“Preparation of Migrastatin Analogs and their Biological Activity” Huang, X.-Y.; Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl. (2004), WO 2004087672.

02 :

“Preparation of Migrastatin Analogs and their Biological Activity” Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl., (2004), WO 2004087673.

01 :

“Synthesis of Epothilones for Therapeutic use as Anticancer Agents” Danishefsky, S. J.; Biswas, K.; Chappell, M. D.; Lin, H.; Njardarson, J. T.; Lee, C.; Rivkin, A.; Chou, T.-C. PCT Int. Appl. (2003), WO 2003022844.